C-178 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 329198-87-0 | Cat. No. | BCP31292 |
| Name | C-178 | ||
| Synonyms | C 178;C178;STING inhibitor C-178; | ||
| SMILES | C1=CC=C2C(=C1)C3=C(O2)C=C(C=C3)NC(=O)C4=CC=C(O4)[N+](=O)[O-] | ||
| Chemical Name | |||
| Formula | C17H10N2O5 | M. Wt | 322.27 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING). | ||
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